Because some of the experimental treatments have yet to be named, or identified, each prospective treatment is listed by its developer, followed by the treatment name or description, the type of treatment including its mechanism, and a brief status update summarizing recent developments. Where applicable, the status updates include links to recent news reports in GEN , as well as to clinical trials pages maintained by U.
In many cases, Chinese authorities, hospitals, and companies are studying potential treatments outside the auspices of their original developers. The trial has been prospectively registered with Chinese authorities. Two other recent coronavirus-related collaborations focus on potential targets.
Can chloroquine really help treat coronavirus patients? | Science | The Guardian
And at least one collaboration announced January 28 focuses on a platform with the promise of future treatments: AbCellera said it and partners will apply its pandemic response platform to develop field-ready medical countermeasures within 60 days of isolation of an unknown viral pathogen. This list is certain to multiply in coming weeks as global health agencies, governments, and drug developers step up efforts against the SARS-CoV-2 virus.
Type: HIV-1 protease inhibitor indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and children 14 days old and older. The Health Commission of Henan Province announced January 31 that three confirmed cases of patients diagnosed with new coronavirus infections recovered after taking Kaletra, a combination of ritonavir and lopinavir.
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As of that date, nucleic acid testing of more than 20 confirmed cases of patients infected with new coronavirus, admitted to hospitals in Zhejiang Province turned negative after taking Kaletra, according to Ascletis Pharma, which is evaluating a combination therapy of its own candidates ASC09 and ritonavir See below. The companies are pursuing approval for trials in China, and FDA authorization under regulations allowing the export of investigational drugs for use in a sudden and immediate national emergency.
Treatment: Single-dose, intranasal vaccine designed to provide systemic immunity.
Coronavirus: DON’T self-medicate. US man dies after taking chloroquine
Status: Altimmune said February 28 that it completed the design and synthesis of the vaccine, and was advancing it toward animal testing and manufacturing. Clinical testing of the vaccine could start as early as August. Type: Recombinant human angiotensin-converting enzyme 2 rhACE2 developed for the treatment of acute lung injury, acute respiratory distress syndrome, and pulmonary arterial hypertension. The randomized, unblinded trial will treat 24 patients for seven days to obtain preliminary data on the impact of rhACE2 on biological, physiologic, and clinical outcomes, as well as safety.
Tamiflu is distributed in the U. Type: Phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties.
Resochin was discovered by Bayer and introduced into clinical practice in to treat malaria. Type: Nucleoside RNA polymerase inhibitor designed to disrupt the viral replication process.
Status: Shown broad-spectrum activity in vitro against more than 20 RNA viruses in coronaviruses and viral disease families that include filoviruses, togaviruses, bunyaviruses, arenaviruses, paramyxoviruses, and flaviviruses. Type: Anti-necrosis drug whose glyco-polymer structure consists of hybrid molecules integrating the Hemoglobin molecule and a proprietary polymer chemical structure.
The University will use the adjuvant to test the viral protein it is developing with its molecular clamp technology, CSL said. Type: Humanized IgG4 monoclonal antibody.
Man dies after self-medicating with chloroquine phosphate to treat coronavirus
Status: CytoDyn plans to offer an update during a March 5 conference call with analysts about its planned filing of an IND and its Phase II clinical trial protocol with the FDA, as the company seeks to evaluate the leronlimab as a coronavirus treatment. CytoDyn and Longen China Group said February 12 they will begin exploring leronlimab as a potential treatment for coronavirus as well as cancer.
Leronlimab has successfully completed nine clinical trials in over people, according to CytoDyn, including meeting its primary endpoints in a pivotal Phase III trial in combination with standard antiretroviral therapies in HIV-infected treatment-experienced patients. Japan has approved Avigan for novel or re-emergent influenza and was previously used to treat Ebola patients in Guinea. Status: GSK agreed to provide Clover with its pandemic adjuvant system for further evaluation of S-Trimer in preclinical studies, the companies said February 24, under a research collaboration whose value was not disclosed.
GSK reasons that Clover could rapidly scale-up and produce large-quantities of a new coronavirus vaccine since it has one of the largest in-house, commercial-scale cGMP biomanufacturing capabilities in China.
Types: Humanized monoclonal antibody targeting PD-1 Camrelizumab ; 5-Da polypeptide hormone secreted by the thymus gland thymosin. Another 50 boxes have been provided to the Chinese Center for Disease Control and Prevention for laboratory-based investigations. Janssen said it is also working closely with global partners to screen its library of antiviral molecules to accelerate discovery of potential COVID treatments.
No commercial partner to take the coronavirus vaccine to market has been identified, the companies said. The primary aim of the Phase I open-label, dose-ranging trial study NCT , which had yet to recruit patients at deadline, is to evaluate the safety and reactogenicity of a 2-dose vaccination schedule of mRNA, given 28 days apart, across 3 dosages in healthy adults. When a virus comes in contact with the nanoviricide, the nanomicelle polymer is designed to fuse with the virus lipid envelope. NanoViricides added that it is working on developing collaborations to advance its COVID program should an effective drug candidate be identified.
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